Dietary supplement testing
Prove every label claim with a calibration you can defend.
Botanical markers, actives, pesticides, residual solvents and contaminants. Every potency and purity result traces back to a calibration. WLTR shows every candidate model side by side and objectively identifies the best fit, so your lab can stand behind the numbers brands, retailers and regulators act on.
Why labs switch to WLTR
Review a full potency or contaminant calibration at once, not one compound at a time.
Chromatography data systems were built to acquire and process data, not to judge a calibration. WLTR does that job objectively, for every analyte, in one view.
- Your CDS shows one analyte at a time, on one small screen.
- Curves are checked by hand, analyte by analyte, often in a spreadsheet.
- The model is chosen by whoever processed the batch, often a junior analyst.
- QA directors sign off without an objective basis for the curve that was chosen.
- Every analyte and every candidate model on one screen, in the Calibration Intelligence dashboard, with multi-analyte visibility.
- Every curve is checked automatically, including accuracy at the specification limit.
- The best fit is determined objectively: same data, same answer, every time.
- QA directors review exceptions only, with one unified calculation behind every calibration.
Hours back every batch
Review by exception instead of one analyte at a time.
Peace of mind for QA
An objective, documented basis for every curve that is signed off.
Accurate data for clients
Results built on the best-fit calibration, not on habit.
More capacity, more revenue
Faster review frees analysts and QA to take on more work.
What WLTR adds to your data
A passing calibration is not the same as the right calibration.
Supplement labs quantitate botanical markers, actives and contaminants against calibrations that are rarely reviewed analyte by analyte. WLTR independently evaluates your calibration standards, ranks how well each established model fits, and documents the result for every analyte on every instrument.
The right fit, backed by evidence
WLTR evaluates the candidate calibration models side by side, so the option your lab reports for each analyte is supported by data rather than habit or software defaults.
Accuracy where decisions are made
Results are judged against label claims, finished product specifications and contaminant limits. WLTR checks every calibration level, including low-end accuracy, so bias near a limit surfaces before a lot is released or rejected.
Every analyte, every instrument
Pesticide, residual solvent and botanical marker panels quantitate many analytes per run. See which compounds and instruments struggle, and trend them over time. Multi-analyte oversight
Records that stand up to review
A documented, reproducible calibration evaluation supports 21 CFR 111 laboratory requirements, ISO/IEC 17025 assessments and customer audits. Audit defensibility
See it for yourself
Same calibration. Three models. Three different answers.
Switch the calibration model and watch how accurately each standard recalculates. The unweighted linear fit posts an r² above 0.998 and still misses badly at the low end, right where quantitation limits and contaminant limits live.
How to read this: each dot is one calibration standard. The closer to the center line, the more accurately that standard is recovered. Pick a regression model:
Recalculated accuracy of each calibration standard. Shaded band shows an example ±20% acceptance window; your method and SOP set the actual criteria. Illustrative data.
Inside WLTR
From ICAL export to a defensible record.
Step 01
Upload the calibration straight from your data system.
Drop in the calibration export from your GC-MS/MS or LC-MS/MS data system. WLTR parses the run and confirms instrument and method context. Nothing about how your instruments acquire or process data changes.
Step 02
Compound lists, mapped once.
Botanical marker and pesticide names rarely match across instruments, software and methods. WLTR maps every analyte to a consistent name so results can be trended across runs and instruments.
Step 03
Every compound, every model, side by side.
WLTR fits each analyte against the candidate calibration models and shows how accurately every standard recalculates, so curvature and low-end bias are visible at a glance.
Step 04
A ranked, documented recommendation.
All 19 acceptance criteria roll up into a ranked model comparison with a clear recommendation and the evidence behind it, ready for data review and your data package.
Your CDS remains the system of record. WLTR is the system of verification. WLTR complements your accredited methods. It does not replace your CDS, your LIMS, or your method SOPs. The WLTR methodology is patented (US 12,038,448 B2).
Where calibration risk hides
The calibration problems supplement testing labs live with.
Many analytes, little review time
Large panels mean individual calibrations get checked against a pass or fail flag rather than examined.
Matrix effects across product forms
Botanicals, gummies, softgels and powders behave differently. A calibration that fits in one matrix can bias results in another.
Low standards near limits
When the lowest standard fails to recalculate, results near a contaminant limit or a specification are in question.
Quadratic fits used to rescue a curve
Switching to a quadratic can make a calibration pass while masking detector saturation or a failing standard.
Retests and missed turnaround
Recurring calibration failures cost retesting and delay the certificates of analysis that brands are waiting on.
Disputed results
An out of specification result or a failed label claim will be challenged by the brand. The calibration behind it needs to hold up.
How it works
Three steps. No change to your methods.
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Export
Export calibration data from your chromatography data system.
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Evaluate
WLTR fits your standards against the candidate calibration models, scores each one, and ranks model performance for each analyte.
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Review and document
Analysts, data reviewers, and QA receive a clear verification result per analyte and instrument, ready for data review, certificates of analysis, and audits.
Regulatory alignment
Built around the standards your lab is assessed against.
| Framework | What it covers | How WLTR supports it |
|---|---|---|
| ISO/IEC 17025:2017 | Competence requirements supplement testing laboratories are accredited against. | Documented, reproducible calibration evidence for accreditation assessments. |
| 21 CFR Part 111 | FDA current good manufacturing practice for dietary supplements, including laboratory operations and specification testing. | Documented calibration evidence behind every specification result. |
| USP <561> Articles of Botanical Origin | Compendial requirements for botanical ingredients, including pesticide residue limits. | Recalculated accuracy and residual checks for each pesticide in the calibration. |
| AOAC Standard Method Performance Requirements | Performance requirements widely used to validate dietary supplement methods. | Model comparison and accuracy evidence across the calibration range. |
Who it is for
Built for the people who sign the report.
- Laboratory directors
- Quality managers
- Analytical chemists
- GC-MS/MS and LC-MS/MS operators
- Data reviewers
- Client services and account managers
Questions
Frequently asked questions
Does WLTR replace our CDS or LIMS?
No. Your chromatography data system remains the system of record and your LIMS continues to manage samples and reporting. WLTR is a verification layer that evaluates the calibration data your instruments already produce.
Does WLTR support 21 CFR 111 and ISO/IEC 17025?
WLTR gives your lab a documented, reproducible evaluation of each calibration, including how the model you report compares with alternatives and how accurately each standard recalculates. That record supports the calibration questions auditors and customers ask.
Which methods does WLTR work with?
Methods that quantitate against a calibration curve, including botanical marker compounds and actives, pesticide residues, residual solvents, mycotoxins and other contaminants by LC-MS/MS, GC-MS/MS and GC.
Do we have to change our methods or SOPs?
WLTR works from calibration data you export after a run. It does not change how your instruments acquire or process data. How WLTR results are referenced in your SOPs is decided by your quality system.
How do we get started?
Apply to the WLTR Pilot Program or request a demo. We will review your workflow and show how WLTR evaluates calibrations from your own instruments.
Pilot program
See what WLTR finds in your supplement calibrations.
Bring a recent calibration. We will show you how each analyte’s reported calibration compares with the best-fit model.
References: 21 CFR Part 111 · ISO/IEC 17025:2017 · WLTR Standards Hub